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Details on Person Resistant ERBB2 KD mutants do not bind AEE788
| Class:Id | FailedReaction:9665278 |
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| _displayName | Resistant ERBB2 KD mutants do not bind AEE788 |
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| _doRelease | TRUE |
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| _timestamp | 2019-11-12 18:17:14 |
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| authored | [InstanceEdit:9665241] Orlic-Milacic, Marija, 2019-10-30 |
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| compartment | [Compartment:70101] cytosol
[Compartment:876] plasma membrane |
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| created | [InstanceEdit:9665281] Orlic-Milacic, Marija, 2019-10-30 |
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| disease | [Disease:1500689] cancer |
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| edited | [InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01 |
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| entityFunctionalStatus | [EntityFunctionalStatus:9665277] loss_of_function of ERBB2 KD mutants (AEE788 resistant):ERBIN:HSP90:CDC37 [plasma membrane] |
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| input | [Complex:9665285] ERBB2 KD mutants (AEE788 resistant):ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens]
[ChemicalDrug:9652364] AEE788 [cytosol] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:9649397] Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib |
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| modified | [InstanceEdit:9665321] Orlic-Milacic, Marija, 2019-10-30
[InstanceEdit:9665323] Orlic-Milacic, Marija, 2019-10-30
[InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | Resistant ERBB2 KD mutants do not bind AEE788 |
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| normalReaction |
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| releaseDate | 2019-12-10 |
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| reviewed | [InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:9665297] R-HSA-9665278.2 |
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| summation | [Summation:9665305] The following ERBB2 KD mutants are resistant to AEE788:
E... |
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| (hasEvent) | [Pathway:9665250] Resistance of ERBB2 KD mutants to AEE788 [Homo sapiens] |
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No pathways have been reviewed or authored by Resistant ERBB2 KD mutants do not bind AEE788 (9665278)
