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Details on Person The following EGFR-binding ERBB2 KD mutants that were shown ...
| Class:Id | Summation:9664997 |
|---|---|
| _displayName | The following EGFR-binding ERBB2 KD mutants that were shown ... |
| _timestamp | 2023-03-22 12:18:42 |
| created | [InstanceEdit:9664995] Orlic-Milacic, Marija, 2019-10-28 |
| modified | [InstanceEdit:9665640] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9665666] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9831085] Orlic-Milacic, Marija, 2023-03-18 [InstanceEdit:9831504] Orlic-Milacic, Marija, 2023-03-22 [InstanceEdit:9831564] Orlic-Milacic, Marija, 2023-03-22 |
| text | The following EGFR-binding ERBB2 KD mutants that were shown to activate RAS/RAF/MAPK signaling, evidenced by activating phosphorylation of ERKs (MAPK1 and MAPK3), are assumed to, like the wild type ERBB2:EGFR heterodimer, directly bind to the GRB2:SOS1 complex: ERBB2 L755S (Trowe et al. 2008, Kancha et al. 2011, Bose et al. 2013, Cocco et al. 2018); ERBB2 L755P (Kancha et al. 2011); ERBB2 I767M (Ng et al. 2015; binding to EGFR indirectly demonstrated by Bose et al. 2013); ERBB2 D769H (Bose et al. 2013); ERBB2 V777L (Kancha et al. 2011, Bose et al. 2013); ERBB2 G778_P780dup (Suzawa et al. 2016); ERBB2 T798M (Kancha et al. 2011, Rexer et al. 2013); ERBB2 T798I (Hanker et al. 2017); ERBB2 V842I (Bose et al. 2013); ERBB2 T862A (Kancha et al. 2011); ERBB2 H878Y (Kancha et al. 2011, Hu, Hu et al. 2015, Hu, Wan et al. 2015); ERBB2 R896C (Bose et al. 2013); ERBB2 L755_T759del (Bose et al. 2013); ERBB2 Y772_A775dup (Wang et al. 2006); Activation of RAS/RAF/MAPK signaling downstream of the following ERBB2 KD cancer mutants has not been studied and they are annotated as candidates: ERBB2 L755M ERBB2 L755W ERBB2 D769Y ERBB2 D769N ERBB2 V777M ERBB2 V777E ERBB2 T733I ERBB2 V842E ERBB2 H878R ERBB2 R896H |
| (summation) | [Reaction:9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 [Homo sapiens] |
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No pathways have been reviewed or authored by The following EGFR-binding ERBB2 KD mutants that were shown ... (9664997)
