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Details on Person Sequestosome 1 (SQSTM1) is an autophagic receptor that recru...
| Class:Id | Summation:9664839 |
|---|---|
| _displayName | Sequestosome 1 (SQSTM1) is an autophagic receptor that recru... |
| _timestamp | 2019-12-02 14:15:50 |
| created | [InstanceEdit:9664866] Varusai, Thawfeek, 2019-10-28 |
| modified | [InstanceEdit:9664912] Varusai, Thawfeek, 2019-10-28 [InstanceEdit:9665186] Varusai, Thawfeek, 2019-10-30 [InstanceEdit:9668897] Varusai, Thawfeek, 2019-12-02 |
| text | Sequestosome 1 (SQSTM1) is an autophagic receptor that recruits ubiquitinated cargo to the autophagosome. SQSTM1 contains a ubiquitin associated (UBA) domain that binds to monoubiquitinated Peroxisomal targeting signal 1 receptor (PEX5) in the peroxisome and an LC3 interacting region (LIR) that binds to Microtubule associated proteins 1A/1B light chain 3B (MAP1LC3B)/LC3 associated with the nascent autophagosome (Pankiv S et al. 2007). Subsequently, the peroxisome is degraded by the autophagy machinery. |
| (summation) | [Reaction:9664855] MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 [Homo sapiens] |
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No pathways have been reviewed or authored by Sequestosome 1 (SQSTM1) is an autophagic receptor that recru... (9664839)
