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Details on Person Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism
| Class:Id | LiteratureReference:9664473 |
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| _displayName | Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism |
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| _timestamp | 2019-10-22 16:37:33 |
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| author | [Person:9664471] Fan, Ying-Xin
[Person:9664470] Wong, Lily
[Person:9664468] Ding, Jinhui
[Person:9664469] Spiridonov, Nikolay A
[Person:9664474] Johnson, Richard C
[Person:9624199] Johnson, Gibbes R |
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| created | [InstanceEdit:9664472] Orlic-Milacic, Marija, 2019-10-22 |
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| journal | J. Biol. Chem. |
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| pages | 1588-96 |
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| pubMedIdentifier | 18039657 |
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| title | Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism |
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| volume | 283 |
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| year | 2008 |
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| (literatureReference) | [EntityWithAccessionedSequence:9664463] ERBB2 G776S [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9664550] p-6Y-ERBB2 G776S [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9664608] p-Y-ERBB2 G776S [plasma membrane] [Homo sapiens]
[Reaction:9664503] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 G776S,(ERBB2 G776C,ERBB2 G776L,ERBB2 G776V) heterodimers [Homo sapiens]
[Reaction:9664567] ERBB2 KD mutants heterodimerize [Homo sapiens]
[Reaction:9664588] ERBB2 KD mutants trans-autophosphorylate [Homo sapiens]
[Reaction:9664950] Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 [Homo sapiens]
[Reaction:9664976] Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 [Homo sapiens]
[Reaction:9664983] Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 [Homo sapiens]
[Reaction:9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants [Homo sapiens] |
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