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Details on Person The internalization of Leishmania amastigotes by macrophages...

Class:IdSummation:9664412
_displayNameThe internalization of Leishmania amastigotes by macrophages...
_timestamp2019-12-11 14:00:46
created[InstanceEdit:9664405] Murillo, Julieth, 2019-10-22
literatureReference[LiteratureReference:9664431] Opsonization modulates Rac-1 activation during cell entry by Leishmania amazonensis
[LiteratureReference:9664373] Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells
modified[InstanceEdit:9670580] Murillo, Julieth, 2019-12-11
textThe internalization of Leishmania amastigotes by macrophages is thought to be mediated mainly through opsonization with immunoglobulins (Igs) which bind FcγRs, stimulating the uptake (Morehead et al 2002 & Padigel et al. 2005). Glycoinositol phospholipids (GIPLs) are the most abundant glycolipids on the surface of the amastigote form of Leishmania parasites and Buxbaum and colleagues showed that IgG1 in mice, binds the GIPL molecules on the amastigote stage of L. mexicana to subsequently induced the phagocytosis through FcγRs (Buxbaum 2013).
(summation)[Reaction:9664397] IgG binds LPG1G2 in the amastigote form of Leishmania [Homo sapiens]
[Reaction:9670578] Mouse IgG binds LPG1G2 in the amastigote form of Leishmania [Mus musculus]
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