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Details on Person Phosphorylation and activation of PLCG due to FCGR3A effect

Class:Id	Reaction:9664278
_displayName	Phosphorylation and activation of PLCG due to FCGR3A effect
_doRelease	TRUE
_timestamp	2020-02-24 17:36:04
authored	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
catalystActivity	[CatalystActivity:2029255] protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643489] protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9664264] Murillo, Julieth, 2019-10-22
disease	[Disease:9674660] cutaneous leishmaniasis
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [Complex:9664266] IgG:Leishmania surface:p-FCGR3As:p-6Y-SYK:PLCG [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2028806] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk [LiteratureReference:2028992] Tyrosine phosphorylation of phospholipase C-gamma 2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils [LiteratureReference:1168981] Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation
modified	[InstanceEdit:9673430] Murillo, Julieth, 2020-01-07 [InstanceEdit:9675740] Murillo, Julieth, 2020-02-05 [InstanceEdit:9675994] Murillo, Julieth, 2020-02-06 [InstanceEdit:9676933] Jassal, Bijay, 2020-02-24 [InstanceEdit:9676966] Murillo, Julieth, 2020-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation and activation of PLCG due to FCGR3A effect
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:9664277] IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-3Y-PLCG [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9664270] Recruitment of PLCgamma to membrane due to FCGR3A effect [Homo sapiens] [Reaction:9664261] Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK [Homo sapiens]
relatedSpecies	[Species:9658193] Leishmania major
releaseDate	2020-03-17
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9664295] R-HSA-9664278.2
summation	[Summation:2028840] PLCG is tyrosine phosphorylated by either SYK or Src kinases...
(hasEvent)	[Pathway:9664323] FCGR3A-mediated IL10 synthesis [Homo sapiens]
(precedingEvent)	[Reaction:9664271] Release of PLCG from FCGR3A [Homo sapiens]
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