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Details on Person SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers
Class:Id Reaction:9664273 _displayName SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers _doRelease TRUE _timestamp 2020-02-24 17:36:22 authored [InstanceEdit:9664264] Murillo, Julieth, 2019-10-22 compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region created [InstanceEdit:9664264] Murillo, Julieth, 2019-10-22 disease [Disease:9674660] cutaneous leishmaniasis edited [InstanceEdit:9675774] Murillo, Julieth, 2020-02-05 input [EntityWithAccessionedSequence:58268] SYK [cytosol] [Homo sapiens] [Complex:9664282] IgG:Lma antigens:FCGR3A:p-CD3 dimers [plasma membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:1861556] A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages [LiteratureReference:1861620] Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase [LiteratureReference:1861684] Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling [LiteratureReference:1861737] Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling [LiteratureReference:1861604] Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells [LiteratureReference:1861686] Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides [LiteratureReference:453188] Molecular mechanism of the Syk activation switch modified [InstanceEdit:9666696] Murillo, Julieth, 2019-11-06 [InstanceEdit:9667168] Murillo, Julieth, 2019-11-07 [InstanceEdit:9667219] Murillo, Julieth, 2019-11-08 [InstanceEdit:9670158] Murillo, Julieth, 2019-12-05 [InstanceEdit:9673431] Murillo, Julieth, 2020-01-07 [InstanceEdit:9674661] Murillo, Julieth, 2020-01-22 [InstanceEdit:9675740] Murillo, Julieth, 2020-02-05 [InstanceEdit:9675994] Murillo, Julieth, 2020-02-06 [InstanceEdit:9676933] Jassal, Bijay, 2020-02-24 [InstanceEdit:9676966] Murillo, Julieth, 2020-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers output [Complex:9664272] IgG:Lma antigens:FCGR3A:p-CD3 dimers:SYK [plasma membrane] [Homo sapiens] precedingEvent
relatedSpecies [Species:9658193] Leishmania major releaseDate 2020-03-17 reviewed [InstanceEdit:9675734] Gregory, David J, 2020-02-04 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9664294] R-HSA-9664273.2 summation [Summation:1861740] SYK is a tyrosine kinase related to ZAP70 that is expressed ... (hasEvent) [Pathway:9664323] FCGR3A-mediated IL10 synthesis [Homo sapiens] [Pathway:9664422] FCGR3A-mediated phagocytosis [Homo sapiens] (precedingEvent) [Reaction:9664261] Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK [Homo sapiens]
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