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Details on Person An influx of calcium ions into the inner hair cell activates...
| Class:Id | Summation:9664049 |
|---|---|
| _displayName | An influx of calcium ions into the inner hair cell activates... |
| _timestamp | 2019-12-14 08:01:38 |
| created | [InstanceEdit:9664104] May, Bruce, 2019-10-21 |
| modified | [InstanceEdit:9670755] May, Bruce, 2019-12-14 |
| text | An influx of calcium ions into the inner hair cell activates exocytosis of glutamate from vesicles docked near ribbon structures on the inner face of the plasma membrane (Roux et al. 2006, Ramakrishnan et al. 2014). Glutamate vesicles of inner hair cells have Otoferlin (OTOF) rather than a synaptotagmin on their surfaces as a calcium sensitive trigger for fusion with the plasma membrane (Roux et al. 2006, Ramakrishnan et al. 2009, Johnson and Chapman 2010, Ramakrishnan et al. 2014, Vincent et al. 2014, Hams et al. 2017, Michalski et al. 2017). Otoferlin interacts with the SNARE proteins Stx1a and Snap25 on the plasma membrane (Ramakrishnan et al. 2009, Johnson and Chapman 2010, Ramakrishnan et al. 2014). The ribbon structure contains Ribeye (a splice variant of Ctbp2, Maxeiner et al. 2016), Piccolino (a short variant of Piccolo, Regus-Leidig et al. 2013), and Bassoon (Khimich et al. 2005), which links the structure to the plasma membrane (tom Dieck et al. 2005), colocalizes calcium channels and vesicles, and promotes replenishment of vesicles (Frank et al. 2010). |
| (summation) | [BlackBoxEvent:9664156] Exocytosis of glutamate from cochlear inner hair cell [Mus musculus] |
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