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Details on Person BIL binds GSTA1, FABP1

Class:Id	Reaction:9663511
_displayName	BIL binds GSTA1, FABP1
_doRelease	TRUE
_timestamp	2025-08-13 19:23:28
authored	[InstanceEdit:9663503] Jassal, Bijay, 2019-10-02
catalystActivity	[CatalystActivity:9955861] molecular carrier activity of GSTA1, FABP1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9955849] molecular carrier activity of GSTA1, FABP1 [cytosol] Bilirubin binding to human liver ligandin (glutathione S-transferase)
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9663503] Jassal, Bijay, 2019-10-02
edited	[InstanceEdit:9663503] Jassal, Bijay, 2019-10-02
input	[SimpleEntity:189386] BIL [cytosol] [DefinedSet:9663507] GSTA1, FABP1 [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9961199] D'Eustachio, Peter, 2025-07-21
isChimeric	FALSE
literatureReference	[LiteratureReference:9663504] Bilirubin binding to human liver ligandin (glutathione S-transferase) [LiteratureReference:9663508] Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions
modified	[InstanceEdit:9663549] Jassal, Bijay, 2019-10-03 [InstanceEdit:9665631] Jassal, Bijay, 2019-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11 [InstanceEdit:9961200] D'Eustachio, Peter, 2025-07-21 [InstanceEdit:9963234] D'Eustachio, Peter, 2025-08-13
name	BIL binds GSTA1, FABP1
negativePrecedingEvent	[NegativePrecedingEvent:9955846] Futile Cycle: BIL dissociates from GSTA1, FABP1 [NegativePrecedingEvent:9955850] BLVRA:Zn2+, BLVRB reduce BV to BIL
output	[Complex:9663490] BIL:GSTA1, FABP1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9661397] SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) [Homo sapiens] [BlackBoxEvent:9661425] BIL:ALB dissociates [Homo sapiens] [Reaction:9661799] SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) [Homo sapiens] [BlackBoxEvent:9661425] BIL:ALB dissociates [Homo sapiens] [Reaction:9661723] SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) [Homo sapiens] [BlackBoxEvent:9661425] BIL:ALB dissociates [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2019-12-10
reviewed	[InstanceEdit:9663548] D'Eustachio, Peter, 2019-10-03 [InstanceEdit:9963235] Hill, David P, 2025-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9663516] R-HSA-9663511.3
structureModified	[InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11
summation	[Summation:9663491] Upon entry into the hepatocyte, bilirubin (BIL) can bind to ...
(hasEvent)	[Pathway:189483] Heme degradation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9663492] BIL dissociates from GSTA1, FABP1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9964793] Update Tracker - [Reaction:9663511] BIL binds GSTA1, FABP1 - v94:[removeCatalystActivity]
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No pathways have been reviewed or authored by BIL binds GSTA1, FABP1 (9663511)