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Details on Person MET channel transports cations from the extracellular region into the cytosol of stereocilia of cochlear outer hair cell

Class:Id	Reaction:9663360
_displayName	MET channel transports cations from the extracellular region into the cytosol of stereocilia of cochlear outer hair cell
_doRelease	TRUE
_timestamp	2021-02-24 17:38:43
authored	[InstanceEdit:9663342] May, Bruce, 2019-09-30
catalystActivity	[CatalystActivity:9663345] monoatomic cation channel activity of MET channel:Tip link:Ush1c:Ush1g:Myo7a:cytoskeleton (OHC) [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9663361] May, Bruce, 2019-09-30
edited	[InstanceEdit:9663342] May, Bruce, 2019-09-30
input	[SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74126] K+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:9663333] TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells [LiteratureReference:9667703] Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells [LiteratureReference:9664085] Tuning Inner-Ear Tip-Link Affinity Through Alternatively Spliced Variants of Protocadherin-15 [LiteratureReference:9659517] Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5 [LiteratureReference:9664678] The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15 [LiteratureReference:9664675] Cadherin 23 is a component of the tip link in hair-cell stereocilia [LiteratureReference:9663377] Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells [LiteratureReference:9664709] Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members [LiteratureReference:9664712] Structural determinants of cadherin-23 function in hearing and deafness [LiteratureReference:9664706] A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells [LiteratureReference:9664694] Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle [LiteratureReference:9664742] Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids [LiteratureReference:9664728] Interactions in the network of Usher syndrome type 1 proteins [LiteratureReference:9664752] Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction [LiteratureReference:9664722] TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia [LiteratureReference:9664744] Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes [LiteratureReference:9664741] Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice [LiteratureReference:9664708] CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival [LiteratureReference:9664740] Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants [LiteratureReference:9664745] TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells [LiteratureReference:9664688] TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells [LiteratureReference:9664736] Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery [LiteratureReference:9664720] The contribution of TMC1 to adaptation of mechanoelectrical transduction channels in cochlear outer hair cells [LiteratureReference:9664717] A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells [LiteratureReference:9664730] Nanomechanics of tip-link cadherins [LiteratureReference:9665077] Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel-like proteins [LiteratureReference:9665071] TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear [LiteratureReference:9665074] The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells [LiteratureReference:9665079] TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells [LiteratureReference:9665075] Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells [LiteratureReference:9667731] Subunit determination of the conductance of hair-cell mechanotransducer channels [LiteratureReference:9663254] Whirlin complexes with p55 at the stereocilia tip during hair cell development [LiteratureReference:9663262] Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia [LiteratureReference:9663226] The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells
modified	[InstanceEdit:9664202] May, Bruce, 2019-10-21 [InstanceEdit:9667746] May, Bruce, 2019-11-16 [InstanceEdit:9668507] May, Bruce, 2019-11-26 [InstanceEdit:9670005] May, Bruce, 2019-12-03 [InstanceEdit:9670755] May, Bruce, 2019-12-14 [InstanceEdit:9671872] May, Bruce, 2019-12-23 [InstanceEdit:9699208] May, Bruce, 2020-09-14 [InstanceEdit:9706573] May, Bruce, 2020-11-07 [InstanceEdit:9706831] May, Bruce, 2020-11-09 [InstanceEdit:9709306] May, Bruce, 2020-12-12 [InstanceEdit:9716763] May, Bruce, 2021-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MET channel transports cations from the extracellular region into the cytosol of stereocilia of cochlear outer hair cell
output	[SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:29804] K+ [cytosol]
regulatedBy	[Requirement:9671862] Requirement by 'Strc:Otog:Otogl [extracellular region]'
regulationReference	[RegulationReference:9671855] Requirement by 'Strc:Otog:Otogl [extracellular region]' Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane
releaseDate	2021-03-23
reviewed	[InstanceEdit:9699205] Dallos, Peter, 2020-09-14 [InstanceEdit:9699206] Furness, David N, 2020-09-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9663388] R-MMU-9663360.2
summation	[Summation:9667736] The mechanoelectrical transduction (MET) channels (also call...
(inferredFrom)	[Reaction:9663363] Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell [Homo sapiens]
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