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Details on Person SLC26A5 (prestin) changes conformation in response to depolarization

Class:Id	BlackBoxEvent:9663354
_displayName	SLC26A5 (prestin) changes conformation in response to depolarization
_doRelease	TRUE
_timestamp	2020-12-12 10:26:45
authored	[InstanceEdit:9663342] May, Bruce, 2019-09-30
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9663361] May, Bruce, 2019-09-30
edited	[InstanceEdit:9663342] May, Bruce, 2019-09-30
inferredFrom	[BlackBoxEvent:9663359] Slc26a5 changes conformation in response to depolarization [Mus musculus] [BlackBoxEvent:9667710] Slc26a5 changes conformation in response to depolarization [Rattus norvegicus]
input	[Complex:9663789] SLC26A5 tetramer (expanded):Cl-,HCO3- [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9695266] Prestin is the motor protein of cochlear outer hair cells
modified	[InstanceEdit:9663818] May, Bruce, 2019-10-12 [InstanceEdit:9664202] May, Bruce, 2019-10-21 [InstanceEdit:9667746] May, Bruce, 2019-11-16 [InstanceEdit:9668300] May, Bruce, 2019-11-25 [InstanceEdit:9695269] May, Bruce, 2020-07-12 [InstanceEdit:9695276] May, Bruce, 2020-07-12 [InstanceEdit:9699208] May, Bruce, 2020-09-14 [InstanceEdit:9706573] May, Bruce, 2020-11-07 [InstanceEdit:9706831] May, Bruce, 2020-11-09 [InstanceEdit:9709306] May, Bruce, 2020-12-12 [InstanceEdit:9709310] May, Bruce, 2020-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLC26A5 (prestin) changes conformation in response to depolarization
output	[Complex:9663798] SLC26A5 tetramer [plasma membrane] [Homo sapiens] [DefinedSet:9663799] Cl-,HCO3- [cytosol]
precedingEvent	[Reaction:9663363] Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell [Homo sapiens]
regulatedBy	[PositiveRegulation:9034472] Positive regulation by 'K+ [cytosol]'
releaseDate	2021-03-23
reviewed	[InstanceEdit:9699206] Furness, David N, 2020-09-14 [InstanceEdit:9699205] Dallos, Peter, 2020-09-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9663383] R-HSA-9663354.2
summation	[Summation:9664032] The membrane protein SLC26A5 (prestin) contracts in the plan...
(hasEvent)	[Pathway:9662361] Sensory processing of sound by outer hair cells of the cochlea [Homo sapiens]
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