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Details on Person PLK2, MAPK14 phosphorylate ADAM17

Class:IdReaction:9662823
_displayNamePLK2, MAPK14 phosphorylate ADAM17
_doReleaseTRUE
_timestamp2020-02-05 09:51:01
authored[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
catalystActivity[CatalystActivity:9662815] protein serine/threonine kinase activity of PLK2, MAPK14 [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9662752] Murillo, Julieth, 2019-09-24
edited[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
input[Complex:9662793] ADAM17(215-827):Zn2+ [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9663402] Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding
[LiteratureReference:9663413] Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades
[LiteratureReference:9663444] Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding
[LiteratureReference:9663395] The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading
[LiteratureReference:9663401] Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide
[LiteratureReference:9663396] Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation
modified[InstanceEdit:9662900] Murillo, Julieth, 2019-09-24
[InstanceEdit:9663453] Murillo, Julieth, 2019-10-01
[InstanceEdit:9664303] Murillo, Julieth, 2019-10-22
[InstanceEdit:9673430] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673793] Murillo, Julieth, 2020-01-09
[InstanceEdit:9675740] Murillo, Julieth, 2020-02-05
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePLK2, MAPK14 phosphorylate ADAM17
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[Complex:9662806] p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2020-03-17
reviewed[InstanceEdit:9675734] Gregory, David J, 2020-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9662882] R-HSA-9662823.2
summation[Summation:9663421] The phosphorylation of disintegrin and metalloproteinase dom...
(hasEvent)[Pathway:9662834] CD163 mediating an anti-inflammatory response [Homo sapiens]
(precedingEvent)[Reaction:9662837] p-S,T-ADAM17(215-827):Zn2+ cleaves CD163 [Homo sapiens]
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No pathways have been reviewed or authored by PLK2, MAPK14 phosphorylate ADAM17 (9662823)
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