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Details on Person FURIN cleaves ADAM17

Class:IdReaction:9662786
_displayNameFURIN cleaves ADAM17
_doReleaseTRUE
_timestamp2020-02-24 10:55:47
authored[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
catalystActivity[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]
compartment[Compartment:20699] Golgi membrane
created[InstanceEdit:9662752] Murillo, Julieth, 2019-09-24
edited[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
input[EntityWithAccessionedSequence:9662835] ADAM17 [Golgi membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9662787] TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity
[LiteratureReference:9662785] Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation
[LiteratureReference:9662830] Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE
[LiteratureReference:9662858] iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS
[LiteratureReference:9662829] The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site
modified[InstanceEdit:9662900] Murillo, Julieth, 2019-09-24
[InstanceEdit:9663453] Murillo, Julieth, 2019-10-01
[InstanceEdit:9664264] Murillo, Julieth, 2019-10-22
[InstanceEdit:9673427] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673793] Murillo, Julieth, 2020-01-09
[InstanceEdit:9675730] Murillo, Julieth, 2020-02-05
[InstanceEdit:9676362] Jassal, Bijay, 2020-02-13
[InstanceEdit:9676363] Jassal, Bijay, 2020-02-13
[InstanceEdit:9676365] Jassal, Bijay, 2020-02-13
[InstanceEdit:9676931] Jassal, Bijay, 2020-02-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFURIN cleaves ADAM17
output[EntityWithAccessionedSequence:9662784] ADAM17(1-214) [Golgi membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9662839] ADAM17(215-824) [Golgi membrane] [Homo sapiens]
precedingEvent
releaseDate2020-03-17
reviewed[InstanceEdit:9675734] Gregory, David J, 2020-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9662879] R-HSA-9662786.2
summation[Summation:9662801] Disintegrin and metalloproteinase domain-containing protein ...
(hasEvent)[Pathway:9662834] CD163 mediating an anti-inflammatory response [Homo sapiens]
(precedingEvent)[Reaction:9662773] ADAM17 binds Zn2+ [Homo sapiens]
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No pathways have been reviewed or authored by FURIN cleaves ADAM17 (9662786)
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