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Details on Person iRHOM2 transports ADAM17 from ER to the Golgi-network

Class:Id	BlackBoxEvent:9662747
_displayName	iRHOM2 transports ADAM17 from ER to the Golgi-network
_doRelease	TRUE
_timestamp	2020-02-06 10:20:07
authored	[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07 [InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
catalystActivity	[CatalystActivity:9662755] cargo receptor activity of iRHOM2 [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:9662752] Murillo, Julieth, 2019-09-24
edited	[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07 [InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
input	[EntityWithAccessionedSequence:9662763] ADAM17 [endoplasmic reticulum lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9662808] Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE [LiteratureReference:9662830] Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE [LiteratureReference:9662858] iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS
modified	[InstanceEdit:9662900] Murillo, Julieth, 2019-09-24 [InstanceEdit:9664303] Murillo, Julieth, 2019-10-22 [InstanceEdit:9666274] Jassal, Bijay, 2019-11-04 [InstanceEdit:9673793] Murillo, Julieth, 2020-01-09 [InstanceEdit:9675740] Murillo, Julieth, 2020-02-05 [InstanceEdit:9675994] Murillo, Julieth, 2020-02-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	iRHOM2 transports ADAM17 from ER to the Golgi-network
output	[EntityWithAccessionedSequence:9662835] ADAM17 [Golgi membrane] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9662878] R-HSA-9662747.2
summation	[Summation:9662780] In mice, inactive rhomboid protein 2 (iRHOM2) has been shown...
(hasEvent)	[Pathway:9662834] CD163 mediating an anti-inflammatory response [Homo sapiens]
(precedingEvent)	[Reaction:9662786] FURIN cleaves ADAM17 [Homo sapiens]
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No pathways have been reviewed or authored by iRHOM2 transports ADAM17 from ER to the Golgi-network (9662747)