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Details on Person ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region

Class:Id	Reaction:9662114
_displayName	ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region
_doRelease	TRUE
_timestamp	2020-12-12 10:24:37
authored	[InstanceEdit:9662112] May, Bruce, 2019-09-20
catalystActivity	[CatalystActivity:9662118] P-type calcium transporter activity of ATP2B2 isoform wa [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9662115] May, Bruce, 2019-09-20
edited	[InstanceEdit:9662112] May, Bruce, 2019-09-20
inferredFrom	[Reaction:9664232] Atp2b2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region [Rattus norvegicus] [Reaction:9668464] Atp2b2 (PMCA2) transports Ca2+ from the cytosol to the extracellular region [Mus musculus]
input	[SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9668462] A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness [LiteratureReference:9668453] Mutations in PMCA2 and hereditary deafness: a molecular analysis of the pump defect
modified	[InstanceEdit:9664202] May, Bruce, 2019-10-21 [InstanceEdit:9664243] May, Bruce, 2019-10-22 [InstanceEdit:9668473] May, Bruce, 2019-11-26 [InstanceEdit:9668474] May, Bruce, 2019-11-26 [InstanceEdit:9698115] May, Bruce, 2020-08-24 [InstanceEdit:9699208] May, Bruce, 2020-09-14 [InstanceEdit:9706573] May, Bruce, 2020-11-07 [InstanceEdit:9706831] May, Bruce, 2020-11-09 [InstanceEdit:9709306] May, Bruce, 2020-12-12 [InstanceEdit:9709310] May, Bruce, 2020-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region
output	[SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:9659515] CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell [Homo sapiens] [Reaction:9659380] Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell [Homo sapiens] [Reaction:9659380] Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9699206] Furness, David N, 2020-09-14 [InstanceEdit:9699205] Dallos, Peter, 2020-09-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9662120] R-HSA-9662114.2
summation	[Summation:9664227] ATP2B2 (wa isoform) is located in the plasma membrane of ste...
(hasEvent)	[Pathway:9662360] Sensory processing of sound by inner hair cells of the cochlea [Homo sapiens] [Pathway:9662361] Sensory processing of sound by outer hair cells of the cochlea [Homo sapiens]
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