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Details on Person SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

Class:Id	Reaction:9661723
_displayName	SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
_doRelease	TRUE
_timestamp	2025-06-11 19:59:54
authored	[InstanceEdit:9661719] Jassal, Bijay, 2019-09-18
catalystActivity	[CatalystActivity:9661702] secondary active transmembrane transporter activity of SLCO2B1-3 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9661719] Jassal, Bijay, 2019-09-18
edited	[InstanceEdit:9661719] Jassal, Bijay, 2019-09-18
input	[SimpleEntity:9661418] BIL [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:194124] Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver [LiteratureReference:9661711] Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant
modified	[InstanceEdit:9661808] Jassal, Bijay, 2019-09-18 [InstanceEdit:9663484] Jassal, Bijay, 2019-10-02 [InstanceEdit:9663549] Jassal, Bijay, 2019-10-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11
name	SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
negativePrecedingEvent	[NegativePrecedingEvent:9955851] ABCC1 transports BIL from cytosol to extracellular region (blood) [NegativePrecedingEvent:9955859] Bacterial GUSB hydrolyses BDG to BIL
output	[SimpleEntity:189386] BIL [cytosol]
precedingEvent	[BlackBoxEvent:9661425] BIL:ALB dissociates [Homo sapiens] [Reaction:9661432] BIL binds ALB [Homo sapiens]
releaseDate	2019-12-10
reviewed	[InstanceEdit:9663548] D'Eustachio, Peter, 2019-10-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9661749] R-HSA-9661723.3
summation	[Summation:9661722] Bilirubin (BIL), the end product of heme catabolism, is take...
(hasEvent)	[Pathway:189483] Heme degradation [Homo sapiens]
(precedingEvent)	[Reaction:9663511] BIL binds GSTA1, FABP1 [Homo sapiens] [NegativePrecedingEvent:9955857] SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) [NegativePrecedingEvent:9955864] SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
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No pathways have been reviewed or authored by SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (9661723)