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Details on Person ABCC1 transports BIL from cytosol to extracellular region (blood)

Class:Id	Reaction:9661405
_displayName	ABCC1 transports BIL from cytosol to extracellular region (blood)
_doRelease	TRUE
_timestamp	2025-06-11 19:59:35
authored	[InstanceEdit:9661421] Jassal, Bijay, 2019-09-16
catalystActivity	[CatalystActivity:266058] ABC-type transporter activity of ABCC1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9661421] Jassal, Bijay, 2019-09-16
edited	[InstanceEdit:9661421] Jassal, Bijay, 2019-09-16
input	[SimpleEntity:189386] BIL [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9661478] Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance [LiteratureReference:9663502] The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin
modified	[InstanceEdit:9661519] Jassal, Bijay, 2019-09-17 [InstanceEdit:9661808] Jassal, Bijay, 2019-09-18 [InstanceEdit:9663503] Jassal, Bijay, 2019-10-02 [InstanceEdit:9663549] Jassal, Bijay, 2019-10-03 [InstanceEdit:9713665] Stephan, Ralf, 2021-01-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11
name	ABCC1 transports BIL from cytosol to extracellular region (blood)
negativePrecedingEvent	[NegativePrecedingEvent:9955842] BIL dissociates from GSTA1, FABP1 [NegativePrecedingEvent:9955852] SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) [NegativePrecedingEvent:9955840] SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) [NegativePrecedingEvent:9955864] SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
output	[SimpleEntity:9661418] BIL [extracellular region]
precedingEvent	[Reaction:189384] BLVRA:Zn2+, BLVRB reduce BV to BIL [Homo sapiens] [Reaction:189398] HMOX1 dimer, HMOX2 cleave heme [Homo sapiens]
releaseDate	2019-12-10
reviewed	[InstanceEdit:9663548] D'Eustachio, Peter, 2019-10-03 [InstanceEdit:9713327] Somers, Julia, 2021-01-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9661465] R-HSA-9661405.4
summation	[Summation:9661491] Bilirubin (BIL), formed in erythroid cells, exits the cell t...
(hasEvent)	[Pathway:189483] Heme degradation [Homo sapiens] [Pathway:9707564] Cytoprotection by HMOX1 [Homo sapiens]
(precedingEvent)	[Reaction:9661432] BIL binds ALB [Homo sapiens] [NegativePrecedingEvent:9955851] ABCC1 transports BIL from cytosol to extracellular region (blood) [NegativePrecedingEvent:9955853] ABCC1 transports BIL from cytosol to extracellular region (blood) [NegativePrecedingEvent:9955863] ABCC1 transports BIL from cytosol to extracellular region (blood) [NegativePrecedingEvent:9955865] ABCC1 transports BIL from cytosol to extracellular region (blood)
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