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Details on Person ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs

Class:IdReaction:9660824
_displayNameADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs
_doReleaseTRUE
_timestamp2020-02-05 09:42:14
authored[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
catalystActivity[CatalystActivity:391182] guanyl-nucleotide exchange factor activity of Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9660823] Murillo, Julieth, 2019-09-12
edited[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
input[Complex:9660817] Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] [Homo sapiens]
[SimpleEntity:29438] GTP [cytosol]
literatureReference[LiteratureReference:391183] Isolation and characterization of the human Gs alpha gene
[LiteratureReference:390777] Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants
[LiteratureReference:390897] Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells
[LiteratureReference:391036] Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein
[LiteratureReference:391019] Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor
modified[InstanceEdit:9673290] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673426] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673793] Murillo, Julieth, 2020-01-09
[InstanceEdit:9675730] Murillo, Julieth, 2020-02-05
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs
output[Complex:9660820] ADORA2B:Ade-Rib:Heterotrimeric G-protein Gs:GTP [plasma membrane] [Homo sapiens]
[SimpleEntity:29420] GDP [cytosol]
precedingEvent
releaseDate2020-03-17
reviewed[InstanceEdit:9675734] Gregory, David J, 2020-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9660831] R-HSA-9660824.2
summation[Summation:751022] The liganded receptor undergoes a conformational change, gen...
(hasEvent)[Pathway:9660821] ADORA2B mediated anti-inflammatory cytokines production [Homo sapiens]
(precedingEvent)[Reaction:9660819] ADORA2B:Ade-Rib:GsGTP dissociates [Homo sapiens]
(updatedInstance)[_UpdateTracker:9939794] Update Tracker - [Reaction:9660824] ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs - v92:[modifyText]
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