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Details on Person Defective RB1 does not translocate to the nucleus
| Class:Id | FailedReaction:9660615 |
| _displayName | Defective RB1 does not translocate to the nucleus |
| _doRelease | TRUE |
| _timestamp | 2020-05-19 11:10:48 |
| authored | [InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07 |
| compartment | [Compartment:70101] cytosol |
| created | [InstanceEdit:9660616] Orlic-Milacic, Marija, 2019-09-10 |
| disease | [Disease:1500689] cancer |
| edited | [InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18 |
| entityFunctionalStatus | [EntityFunctionalStatus:9660654] loss_of_function and partial_loss_of_function of RB1 mutants (localization) [cytosol] |
| input | [CandidateSet:9660658] RB1 mutants (localization) [cytosol] [Homo sapiens] |
| isChimeric | FALSE |
| literatureReference | [LiteratureReference:9661058] Deletion of RB exons 24 and 25 causes low-penetrance retinoblastoma |
| modified | [InstanceEdit:9660676] Orlic-Milacic, Marija, 2019-09-11 [InstanceEdit:9661063] Orlic-Milacic, Marija, 2019-09-13 [InstanceEdit:9661068] Orlic-Milacic, Marija, 2019-09-13 [InstanceEdit:9687148] Orlic-Milacic, Marija, 2020-05-06 [InstanceEdit:9687149] Orlic-Milacic, Marija, 2020-05-06 [InstanceEdit:9689369] Orlic-Milacic, Marija, 2020-05-18 [InstanceEdit:9689390] Orlic-Milacic, Marija, 2020-05-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
| name | Defective RB1 does not translocate to the nucleus |
| normalReaction |
|
| releaseDate | 2020-06-10 |
| reviewed | [InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17 |
| reviewStatus | [ReviewStatus:9821382] five stars |
| species | [Species:48887] Homo sapiens |
| stableIdentifier | [StableIdentifier:9660617] R-HSA-9660615.2 |
| summation | [Summation:9660614] Amino acid residues 860-876 in the C-terminal part of RB1 co... |
| (hasEvent) | [Pathway:9661070] Defective translocation of RB1 mutants to the nucleus [Homo sapiens] |
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