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Details on Person PP1-mediated dephosphorylation of RAF occurs in the context ...
| Class:Id | Summation:9660539 |
|---|---|
| _displayName | PP1-mediated dephosphorylation of RAF occurs in the context ... |
| _timestamp | 2019-09-09 19:56:16 |
| created | [InstanceEdit:9660535] Rothfels, Karen, 2019-09-09 |
| text | PP1-mediated dephosphorylation of RAF occurs in the context of a ternary complex consisting of SHOC2 and the RAS protein family member MRAS in its GTP-bound form (Rodriguez-Viciano et al, 2006; Young et al, 2013; reviewed in Simanshu et al, 2017). Consistent with a role of this ternary complex in promoting RAF signaling, activating mutations in SHOC2, MRAS and PP1 are associated with increased RAF pathway activity in Noonan syndrome (Cordeddu et al, 2009; Gripp et al, 2016; Motta et al, 2016; Higgin et al, 2017; Motta et al, 2019a,b; Young et al, 2018). |
| (summation) | [Reaction:9660538] Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs [Homo sapiens] |
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No pathways have been reviewed or authored by PP1-mediated dephosphorylation of RAF occurs in the context ... (9660539)
