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Details on Person Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs
Class:Id Reaction:9660538 _displayName Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs _doRelease TRUE _timestamp 2020-05-27 14:31:52 authored [InstanceEdit:9664643] Rothfels, Karen, 2019-10-25 catalystActivity [CatalystActivity:9660534] protein serine/threonine phosphatase activity of mutant MRAS:SHOC2:PP1 complexes [plasma membrane] compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol created [InstanceEdit:9660535] Rothfels, Karen, 2019-09-09 disease [Disease:6802289] Noonan syndrome [Disease:2327998] esophageal carcinoma edited [InstanceEdit:9690121] Rothfels, Karen, 2020-05-26 entityFunctionalStatus [EntityFunctionalStatus:9660501] gain_of_function of mutant MRAS:SHOC2:PP1 complexes [plasma membrane] input [Complex:5672707] inactive RAFs:YWHAB dimer [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol] isChimeric FALSE literatureReference [LiteratureReference:9660339] A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity [LiteratureReference:9660364] An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth [LiteratureReference:9654499] RAS Proteins and Their Regulators in Human Disease [LiteratureReference:9660412] Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair [LiteratureReference:9660335] A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair [LiteratureReference:9660422] SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signalling [LiteratureReference:9660390] Elucidation of MRAS -mediated Noonan syndrome with cardiac hypertrophy [LiteratureReference:9660380] Clinical and functional characterization of a novel RASopathy-causing SHOC2 mutation associated with prenatal-onset hypertrophic cardiomyopathy [LiteratureReference:9660358] Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy [LiteratureReference:9660426] SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis modified [InstanceEdit:9664644] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665667] Rothfels, Karen, 2019-10-31 [InstanceEdit:9676028] Rothfels, Karen, 2020-02-06 [InstanceEdit:9676768] Rothfels, Karen, 2020-02-20 [InstanceEdit:9689467] Rothfels, Karen, 2020-05-19 [InstanceEdit:9689469] Rothfels, Karen, 2020-05-19 [InstanceEdit:9690121] Rothfels, Karen, 2020-05-26 [InstanceEdit:9690154] Rothfels, Karen, 2020-05-27 [InstanceEdit:9690188] Rothfels, Karen, 2020-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs normalReaction
output [Complex:5672728] dephosphorylated inactive RAFS:YWHAB dimer [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol] precedingEvent
releaseDate 2020-06-10 reviewed [InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9660540] R-HSA-9660538.2 summation [Summation:9660539] PP1-mediated dephosphorylation of RAF occurs in the context ... (hasEvent) [Pathway:9726842] Gain-of-function MRAS complexes activate RAF signaling [Homo sapiens]
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