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Details on Person SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex

Class:Id	FailedReaction:9660536
_displayName	SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex
_doRelease	TRUE
_timestamp	2020-05-27 14:34:23
authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
catalystActivity	[CatalystActivity:9665021] protein serine/threonine phosphatase activity of SHOC2 M173I:MRAS:PP1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9660535] Rothfels, Karen, 2019-09-09
disease	[Disease:6802289] Noonan syndrome
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
entityFunctionalStatus	[EntityFunctionalStatus:9660489] loss_of_function of SHOC2 M173I:MRAS:PP1 [plasma membrane]
input	[Complex:5672707] inactive RAFs:YWHAB dimer [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9660310] A Novel SHOC2 Variant in Rasopathy [LiteratureReference:9660339] A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
modified	[InstanceEdit:9664644] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665022] Rothfels, Karen, 2019-10-28 [InstanceEdit:9665667] Rothfels, Karen, 2019-10-31 [InstanceEdit:9676028] Rothfels, Karen, 2020-02-06 [InstanceEdit:9676768] Rothfels, Karen, 2020-02-20 [InstanceEdit:9689467] Rothfels, Karen, 2020-05-19 [InstanceEdit:9689469] Rothfels, Karen, 2020-05-19 [InstanceEdit:9690121] Rothfels, Karen, 2020-05-26 [InstanceEdit:9690154] Rothfels, Karen, 2020-05-27 [InstanceEdit:9690196] Rothfels, Karen, 2020-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex
normalReaction	[Reaction:9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs [Homo sapiens]
precedingEvent	[Reaction:5672951] Inactive RAFs bind YWHAB [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9660541] R-HSA-9660536.2
summation	[Summation:9660456] A loss-of-function mutation in SHOC2 has been identified in ...
(hasEvent)	[Pathway:9726840] SHOC2 M1731 mutant abolishes MRAS complex function [Homo sapiens]
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