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Details on Person A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity

Class:IdLiteratureReference:9660339
_displayNameA phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
_timestamp2019-09-09 19:46:38
author[Person:9650999] Rodriguez-Viciana, Pablo
[Person:9660343] Oses-Prieto, Juan
[Person:9660341] Burlingame, Alma
[Person:9660340] Fried, Mike
[Person:3768946] McCormick, Frank
created[InstanceEdit:9660342] Rothfels, Karen, 2019-09-09
journalMol. Cell
pages217-30
pubMedIdentifier16630891
titleA phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
volume22
year2006
(literatureReference)[Reaction:9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs [Homo sapiens]
[FailedReaction:9660536] SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex [Homo sapiens]
[Pathway:9660537] Signaling by MRAS-complex mutants [Homo sapiens]
[Reaction:9660538] Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs [Homo sapiens]
[Pathway:9726840] SHOC2 M1731 mutant abolishes MRAS complex function [Homo sapiens]
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