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Details on Person UniProt:P56974 Nrg2
| Class:Id | ReferenceGeneProduct:96603 |
|---|---|
| _chainChangeLog | propeptide:1-19 added on Fri February 6 2015;chain:20-756 added on Fri February 6 2015;chain:20-314 added on Fri February 6 2015 |
| _displayName | UniProt:P56974 Nrg2 |
| _timestamp | 2023-11-03 16:24:34 |
| chain | propeptide:1-19 chain:20-756 chain:20-314 |
| checksum | 51D85DC918BE678E |
| comment | FUNCTION Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.SUBUNIT Interacts with ERBB3 and ERBB4.SUBCELLULAR LOCATION Does not seem to be active.SUBCELLULAR LOCATION Additional isoforms seem to exist.TISSUE SPECIFICITY Highest expression in the brain, with lower levels in the lung. In the cerebellum, found in granule and Purkinje cells.DOMAIN The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).DOMAIN ERBB receptor binding is elicited entirely by the EGF-like domain.PTM Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.PTM Extensive glycosylation precedes the proteolytic cleavage.SIMILARITY Belongs to the neuregulin family. |
| description | recommendedName: Pro-neuregulin-2, membrane-bound isoform shortName: Pro-NRG2 component recommendedName: Neuregulin-2 shortName: NRG-2 alternativeName: Divergent of neuregulin 1 shortName: DON-1 /component |
| geneName | Nrg2 |
| identifier | P56974 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Disulfide bond EGF-like domain Glycoprotein Growth factor Immunoglobulin domain Membrane Reference proteome Secreted Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Nrg2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NRG2_MOUSE |
| sequenceLength | 756 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:240197] UniProt:P56974-2 Nrg2 [Mus musculus] [ReferenceIsoform:240198] UniProt:P56974-3 Nrg2 [Mus musculus] [ReferenceIsoform:240199] UniProt:P56974-4 Nrg2 [Mus musculus] [ReferenceIsoform:404483] UniProt:P56974-1 Nrg2 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9612659] Nrg2 [extracellular region] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P56974 Nrg2 (96603)
