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Details on Person ABCC1 transports xenobiotics out of the cell

Class:Id	Reaction:9660098
_displayName	ABCC1 transports xenobiotics out of the cell
_doRelease	FALSE
_timestamp	2019-09-16 14:29:48
catalystActivity	[CatalystActivity:9660097] ATPase-coupled transmembrane transporter activity of ABCC1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9661308] ATPase-coupled transmembrane transporter activity of ABCC1 [plasma membrane] Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1)
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9660094] Orlic-Milacic, Marija, 2019-09-09
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [DefinedSet:9660103] xenobiotics (ABCC1) [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9661238] Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity [LiteratureReference:9661265] Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport [LiteratureReference:9661281] Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2 [LiteratureReference:9661286] Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo [LiteratureReference:9661294] Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells [LiteratureReference:9661311] Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1 [LiteratureReference:9661299] The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal [LiteratureReference:9661325] Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1) [LiteratureReference:9661344] The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice [LiteratureReference:9661354] Identification and characterization of the canine multidrug resistance-associated protein [LiteratureReference:9661351] Enhancement of glucuronosyl etoposide transport by glutathione in multidrug resistance-associated protein-overexpressing cells [LiteratureReference:9661390] Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles
modified	[InstanceEdit:9660578] Orlic-Milacic, Marija, 2019-09-09 [InstanceEdit:9661026] Orlic-Milacic, Marija, 2019-09-12 [InstanceEdit:9661245] Orlic-Milacic, Marija, 2019-09-14 [InstanceEdit:9661264] Orlic-Milacic, Marija, 2019-09-15 [InstanceEdit:9661272] Orlic-Milacic, Marija, 2019-09-15 [InstanceEdit:9661284] Orlic-Milacic, Marija, 2019-09-15 [InstanceEdit:9661296] Orlic-Milacic, Marija, 2019-09-15 [InstanceEdit:9661318] Orlic-Milacic, Marija, 2019-09-15 [InstanceEdit:9661326] Orlic-Milacic, Marija, 2019-09-15 [InstanceEdit:9661349] Orlic-Milacic, Marija, 2019-09-16 [InstanceEdit:9661361] Orlic-Milacic, Marija, 2019-09-16 [InstanceEdit:9661393] Orlic-Milacic, Marija, 2019-09-16
name	ABCC1 transports xenobiotics out of the cell
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [DefinedSet:9660099] xenobiotics (ABCC1) [extracellular region]
regulatedBy	[NegativeRegulation:9660572] Negative regulation by 'ABCC1:ABCC1 inhibitors [plasma membrane]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9660109] R-HSA-9660098.1
summation	[Summation:9661024] ABCC1 (also known as MRP1, or multidrug resistance protein 1...
(hasEvent)	[Pathway:9659652] ATPase-Coupled Xenobiotic Transmembrane Transporters [Homo sapiens]
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No pathways have been reviewed or authored by ABCC1 transports xenobiotics out of the cell (9660098)