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Details on Person ABCB1 binds ABCB1 inhibitors

Class:Id	Reaction:9659967
_displayName	ABCB1 binds ABCB1 inhibitors
_doRelease	FALSE
_timestamp	2019-09-23 02:23:56
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9659971] Orlic-Milacic, Marija, 2019-09-06
input	[EntityWithAccessionedSequence:1457534] ABCB1 [plasma membrane] [Homo sapiens] [DefinedSet:9659966] ABCB1 inhibitors [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9661019] Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells [LiteratureReference:9661014] Interaction of rat kidney P-glycoprotein with a urinary component and various drugs including cyclosporin A [LiteratureReference:9662356] Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells
modified	[InstanceEdit:9660609] Orlic-Milacic, Marija, 2019-09-10 [InstanceEdit:9661023] Orlic-Milacic, Marija, 2019-09-12 [InstanceEdit:9662357] Orlic-Milacic, Marija, 2019-09-23
name	ABCB1 binds ABCB1 inhibitors
output	[Complex:9659968] ABCB1:ABCB1 inhibitors [plasma membrane] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9659973] R-HSA-9659967.1
summation	[Summation:9659965] Binding of ABCB1 (also known as MDR1, P-glycoprotein, or PGP...
(hasEvent)	[Pathway:9659652] ATPase-Coupled Xenobiotic Transmembrane Transporters [Homo sapiens]
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No pathways have been reviewed or authored by ABCB1 binds ABCB1 inhibitors (9659967)