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Details on Person RB1 translocates to the nucleus

Class:IdBlackBoxEvent:9659820
_displayNameRB1 translocates to the nucleus
_doReleaseTRUE
_timestamp2020-05-19 11:32:26
authored[InstanceEdit:9018019] Orlic-Milacic, Marija, 2017-08-29
compartment[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created[InstanceEdit:9659824] Orlic-Milacic, Marija, 2019-09-06
edited[InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18
input[EntityWithAccessionedSequence:9660621] RB1 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9660620] A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity
modified[InstanceEdit:9660624] Orlic-Milacic, Marija, 2019-09-10
[InstanceEdit:9661228] Orlic-Milacic, Marija, 2019-09-14
[InstanceEdit:9687332] Orlic-Milacic, Marija, 2020-05-07
[InstanceEdit:9689391] Orlic-Milacic, Marija, 2020-05-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRB1 translocates to the nucleus
output[EntityWithAccessionedSequence:68642] RB1 [nucleoplasm] [Homo sapiens]
releaseDate2020-06-10
reviewed[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9659825] R-HSA-9659820.2
summation[Summation:9661226] Amino acid residues 860-876 in the C terminal part of RB1 co...
(hasEvent)[Pathway:69231] Cyclin D associated events in G1 [Homo sapiens]
(normalReaction)[FailedReaction:9660615] Defective RB1 does not translocate to the nucleus [Homo sapiens]
(precedingEvent)[Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens]
[Reaction:9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes [Homo sapiens]
[Reaction:9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 [Homo sapiens]
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No pathways have been reviewed or authored by RB1 translocates to the nucleus (9659820)