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Details on Person MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs

Class:IdReaction:9658445
_displayNameMRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
_doReleaseTRUE
_timestamp2020-05-27 01:31:52
authored[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
catalystActivity[CatalystActivity:9658443] protein serine/threonine phosphatase activity of S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9658450] Rothfels, Karen, 2019-08-14
edited[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
input[Complex:5672707] inactive RAFs:YWHAB dimer [cytosol] [Homo sapiens]
[SimpleEntity:29356] H2O [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
[LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks
[LiteratureReference:208163] Dephosphorylation of Ser-259 regulates Raf-1 membrane association
[LiteratureReference:5672478] Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation
[LiteratureReference:208298] Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
[LiteratureReference:9660339] A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
[LiteratureReference:9660364] An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth
[LiteratureReference:9654499] RAS Proteins and Their Regulators in Human Disease
[LiteratureReference:9660412] Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair
[LiteratureReference:9660335] A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair
[LiteratureReference:9660390] Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy
[LiteratureReference:5674056] Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration
[LiteratureReference:5674053] Ras-Raf signaling needs prohibitin
[LiteratureReference:5674049] Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway
modified[InstanceEdit:9658456] Rothfels, Karen, 2019-08-14
[InstanceEdit:9660562] Rothfels, Karen, 2019-09-09
[InstanceEdit:9664644] Rothfels, Karen, 2019-10-25
[InstanceEdit:9665667] Rothfels, Karen, 2019-10-31
[InstanceEdit:9676028] Rothfels, Karen, 2020-02-06
[InstanceEdit:9676768] Rothfels, Karen, 2020-02-20
[InstanceEdit:9686661] Rothfels, Karen, 2020-05-04
[InstanceEdit:9690154] Rothfels, Karen, 2020-05-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
output[Complex:5672728] dephosphorylated inactive RAFS:YWHAB dimer [cytosol] [Homo sapiens]
[SimpleEntity:29372] Pi [cytosol]
precedingEvent
releaseDate2020-06-10
reviewed[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9658453] R-HSA-9658445.2
summation[Summation:9660453] Activation of RAF upon growth factor stimulation depends on ...
(hasEvent)[Pathway:5673000] RAF activation [Homo sapiens]
(normalReaction)[FailedReaction:9660536] SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex [Homo sapiens]
[Reaction:9660538] Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs [Homo sapiens]
(updatedInstance)[_UpdateTracker:9835771] Update Tracker - [Reaction:9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - v85:[modifyText]
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No pathways have been reviewed or authored by MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (9658445)
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