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Details on Person The apolipoprotein D (APOD) gene is transcribed to yield mRN...
| Class:Id | Summation:9657860 |
|---|---|
| _displayName | The apolipoprotein D (APOD) gene is transcribed to yield mRN... |
| _timestamp | 2019-08-09 09:02:21 |
| created | [InstanceEdit:9657834] Shamovsky, Veronica, 2019-08-09 |
| literatureReference | [LiteratureReference:5229265] Cloning and expression of human apolipoprotein D cDNA [LiteratureReference:9657833] Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target [LiteratureReference:9657849] Activation of liver X receptor suppresses angiogenesis via induction of ApoD [LiteratureReference:9657770] Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress [LiteratureReference:9657796] Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse |
| text | The apolipoprotein D (APOD) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. APOD is an atypical apolipoprotein that belongs to the lipocalin family, and is expressed by a wide variety of cells and tissues (Drayna D et al. 1986). The liver X receptor α (LXRα, NR1H3) and LXRβ (NR1H2) were found to regulate the expression of the APOD gene in cultured cells and in vivo (Hummasti S et al. 2004; Lai C-J et al. 2017). Synthetic LXR agonist treatment of mouse adipocytes (3T3-L1 cells) and human umbilical vein endothelial cells (HUVECs) resulted in increased mRNA and protein levels of APOD (Hummasti S et al. 2004; Lai C-J et al. 2017). An LXR response element (LXRE) was identified in the human APOD gene promoter, and binding of LXRα (NR1H3):RXRa heterodimers was demonstrated by electrophoretic mobility shift assay (EMSA) and luciferase cell reporter assay (Hummasti S et al. 2004). Mice treated with synthetic LXR agonists exhibited increased APOD mRNA levels in adipose tissue, skeletal muscle and cerebellum, but not liver (Hummasti S et al. 2004; Repa JJ et al. 2007). In humans, APOD is found in the plamsa, associated with high-density lipoprotein (HDL), and polymorphisms have been linked to metabolic disease. APOD has also been suggested to be neuroprotective (Pascua-Maestro R et al 2019). |
| (summation) | [BlackBoxEvent:9657767] Expression of APOD regulated by NR1H2 or NR1H3 [Homo sapiens] |
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