Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person factor XIa binds APP(18-770)

Class:IdReaction:9657706
_displayNamefactor XIa binds APP(18-770)
_doReleaseTRUE
_timestamp2026-01-27 16:19:49
authored[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
compartment[Compartment:984] extracellular region
created[InstanceEdit:9657703] Shamovsky, Veronica, 2019-08-09
edited[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
goBiologicalProcess[GO_BiologicalProcess:1221431] negative regulation of blood coagulation, intrinsic pathway
input[EntityWithAccessionedSequence:49335] APP(18-770) [extracellular region] [Homo sapiens]
[Complex:158130] factor XIa:GPIb:GPIX:GPV complex [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
literatureReference[LiteratureReference:9660294] Progress curve analysis of the kinetics with which blood coagulation factor XIa is inhibited by protease nexin-2
[LiteratureReference:9660296] Protease nexin II interactions with coagulation factor XIa are contained within the Kunitz protease inhibitor domain of protease nexin II and the factor XIa catalytic domain
modified[InstanceEdit:9660295] Shamovsky, Veronica, 2019-09-09
[InstanceEdit:9672199] Shamovsky, Veronica, 2019-12-23
[InstanceEdit:9674491] Shamovsky, Veronica, 2020-01-13
[InstanceEdit:9935201] Shamovsky, Veronica, 2025-01-13
[InstanceEdit:9938625] Shamovsky, Veronica, 2025-02-18
[InstanceEdit:9938676] Shamovsky, Veronica, 2025-02-18
[InstanceEdit:9938860] Shamovsky, Veronica, 2025-02-20
[InstanceEdit:9979563] Shamovsky, Veronica, 2026-01-20
[InstanceEdit:9980357] Shamovsky, Veronica, 2026-01-27
namefactor XIa binds APP(18-770)
factor XIa binds PN2
output[Complex:9657716] factor XIa:APP (18-770) [extracellular region] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:9653824] Positive regulation by 'Heparins [plasma membrane]'
releaseDate2026-03-25
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9657717] R-HSA-9657706.1
summation[Summation:9657696] This Reactome event shows interaction between the activated ...
(hasEvent)[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens]
[Pathway:9769739] Regulation of clotting cascade [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by factor XIa binds APP(18-770) (9657706)