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Details on Person Cysmethynil binds ICMT:Zn2+

Class:IdReaction:9656775
_displayNameCysmethynil binds ICMT:Zn2+
_doReleaseTRUE
_timestamp2020-05-27 01:26:15
authored[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
compartment[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created[InstanceEdit:9656777] Rothfels, Karen, 2019-08-02
disease[Disease:1500689] cancer
edited[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
input[ChemicalDrug:9656757] Cysmethynil [cytosol]
[Complex:6788652] ICMT:Zn2+ [endoplasmic reticulum membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9653453] Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate
[LiteratureReference:9653386] Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth
[LiteratureReference:9656458] Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT)
[LiteratureReference:9656508] Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia
[LiteratureReference:9656501] Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer
[LiteratureReference:6788765] An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo
[LiteratureReference:9656464] Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt)
modified[InstanceEdit:9664644] Rothfels, Karen, 2019-10-25
[InstanceEdit:9665667] Rothfels, Karen, 2019-10-31
[InstanceEdit:9676028] Rothfels, Karen, 2020-02-06
[InstanceEdit:9676768] Rothfels, Karen, 2020-02-20
[InstanceEdit:9686660] Rothfels, Karen, 2020-05-04
[InstanceEdit:9690154] Rothfels, Karen, 2020-05-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCysmethynil binds ICMT:Zn2+
output[Complex:9656776] ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] [Homo sapiens]
releaseDate2020-06-10
reviewed[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9656779] R-HSA-9656775.2
summation[Summation:9656537] Cysmethnil is a small molecule inhibitor of ICMT that has be...
(hasEvent)[Pathway:9648002] RAS processing [Homo sapiens]
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No pathways have been reviewed or authored by Cysmethynil binds ICMT:Zn2+ (9656775)
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