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Details on Person Defective OGG1 mutants show decreased binding to 8-oxoguanine
| Class:Id | FailedReaction:9656254 |
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| _displayName | Defective OGG1 mutants show decreased binding to 8-oxoguanine |
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| _doRelease | TRUE |
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| _timestamp | 2019-10-16 16:10:47 |
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| authored | [InstanceEdit:9656251] Orlic-Milacic, Marija, 2019-07-30 |
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| compartment | [Compartment:7660] nucleoplasm |
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| created | [InstanceEdit:9656251] Orlic-Milacic, Marija, 2019-07-30 |
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| disease | [Disease:1500689] cancer
[Disease:8863054] Alzheimer's disease |
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| edited | [InstanceEdit:9663704] Orlic-Milacic, Marija, 2019-10-10 |
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| entityFunctionalStatus | [EntityFunctionalStatus:9656305] loss_of_function of OGG1 mutants (8oxoG binding) [nucleoplasm] |
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| input | [DefinedSet:9656269] OGG1 mutants (8oxoG binding) [nucleoplasm] [Homo sapiens]
[GenomeEncodedEntity:110184] (8oxoG:Cyt)-dsDNA [nucleoplasm] [Homo sapiens] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:9656282] Identification and characterization of OGG1 mutations in patients with Alzheimer's disease |
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| modified | [InstanceEdit:9656308] Orlic-Milacic, Marija, 2019-07-31
[InstanceEdit:9663709] Orlic-Milacic, Marija, 2019-10-10
[InstanceEdit:9663884] Orlic-Milacic, Marija, 2019-10-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | Defective OGG1 mutants show decreased binding to 8-oxoguanine |
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| normalReaction |
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| releaseDate | 2019-12-10 |
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| reviewed | [InstanceEdit:9663702] Vlahopoulos, Spiros, 2019-10-02
[InstanceEdit:9663703] Boldogh, Istvan, 2019-10-08 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:9656263] R-HSA-9656254.2 |
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| summation | [Summation:9656304] OGG1 missense mutants reported in Alzheimer's disease, OGG1 ... |
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| (hasEvent) | [Pathway:9656255] Defective OGG1 Substrate Binding [Homo sapiens] |
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No pathways have been reviewed or authored by Defective OGG1 mutants show decreased binding to 8-oxoguanine (9656254)
