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Details on Person Dissociation of RAS:RAF1 mutant complex

Class:Id	Reaction:9656209
_displayName	Dissociation of RAS:RAF1 mutant complex
_doRelease	TRUE
_timestamp	2020-05-27 13:30:30
authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9656210] Rothfels, Karen, 2019-07-27
disease	[Disease:9651116] Costello syndrome [Disease:9651118] LEOPARD syndrome [Disease:6802289] Noonan syndrome [Disease:1500689] cancer [Disease:6788675] hypertrophic cardiomyopathy
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
entityFunctionalStatus	[EntityFunctionalStatus:9656200] gain_of_function of activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
input	[Complex:9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5672144] "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway
modified	[InstanceEdit:9664644] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665667] Rothfels, Karen, 2019-10-31 [InstanceEdit:9676028] Rothfels, Karen, 2020-02-06 [InstanceEdit:9676768] Rothfels, Karen, 2020-02-20 [InstanceEdit:9689467] Rothfels, Karen, 2020-05-19 [InstanceEdit:9689469] Rothfels, Karen, 2020-05-19 [InstanceEdit:9690121] Rothfels, Karen, 2020-05-26 [InstanceEdit:9690154] Rothfels, Karen, 2020-05-27 [InstanceEdit:9690184] Rothfels, Karen, 2020-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of RAS:RAF1 mutant complex
normalReaction	[Reaction:5672980] Dissociation of RAS:RAF complex [Homo sapiens]
output	[DefinedSet:169289] p-T,Y MAPKs [cytosol] [Homo sapiens] [CandidateSet:5672717] RAF/MAPK scaffolds [cytosol] [Homo sapiens] [DefinedSet:5672721] p-2S MAP2K homo/heterodimers [cytosol] [Homo sapiens] [Complex:9656176] p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9656214] MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants [Homo sapiens] [Reaction:9656215] RAF1 mutant complexes phosphorylate MAP2K dimer [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9656219] R-HSA-9656209.2
summation	[Summation:9655943] After phosphorylation of MAPKs by complexes containing RAF1 ...
(hasEvent)	[Pathway:9656223] Signaling by RAF1 mutants [Homo sapiens]
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