Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person RAF1 mutants in cancer and germline disorders such as Noonan...
| Class:Id | Summation:9655954 |
|---|---|
| _displayName | RAF1 mutants in cancer and germline disorders such as Noonan... |
| _timestamp | 2020-05-27 14:33:32 |
| created | [InstanceEdit:9655955] Rothfels, Karen, 2019-07-27 |
| modified | [InstanceEdit:9690193] Rothfels, Karen, 2020-05-27 |
| text | RAF1 mutants in cancer and germline disorders such as Noonan syndrome undergo enhanced dimerization and activation with BRAF, leading to high levels of downstream signaling. This has been observed even in cases of RAF1 mutations with abrogated or impaired kinase activity (Razzaque et al, 2007; Pandit et al, 2007; Kobayashi et al, 2010; Wu et al, 2012; Krauthammer et al, 2015; reviewed in Rauen, 2013). |
| (summation) | [Reaction:9656212] Phosphorylation of RAF1 mutants [Homo sapiens] |
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No pathways have been reviewed or authored by RAF1 mutants in cancer and germline disorders such as Noonan... (9655954)
