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Details on Person Cleavage of factor XII variant by plasmin

Class:IdBlackBoxEvent:9655045
_displayNameCleavage of factor XII variant by plasmin
_doReleaseFALSE
_timestamp2024-11-08 16:59:59
authored[InstanceEdit:9660568] Shamovsky, Veronica, 2019-09-09
catalystActivity[CatalystActivity:158743] serine-type endopeptidase activity of Plasmin [extracellular region]
catalystActivityReference[CatalystActivityReference:9655052] serine-type endopeptidase activity of Plasmin [extracellular region] Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:9655048] Shamovsky, Veronica, 2019-07-23
disease[Disease:9653241] hereditary angioedema
edited[InstanceEdit:9690131] Shamovsky, Veronica, 2020-05-26
entityFunctionalStatus[EntityFunctionalStatus:9653254] gain_of_function of F12 variant [extracellular region]
input[DefinedSet:9653247] F12 variant [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9653250] Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations
[LiteratureReference:9653227] A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain
[LiteratureReference:9655041] Factor XII truncation accelerates activation in solution
modified[InstanceEdit:9655833] Shamovsky, Veronica, 2019-07-26
[InstanceEdit:9676086] Shamovsky, Veronica, 2020-02-07
[InstanceEdit:9676350] Shamovsky, Veronica, 2020-02-13
[InstanceEdit:9681504] Shamovsky, Veronica, 2020-04-02
[InstanceEdit:9686299] Shamovsky, Veronica, 2020-04-29
[InstanceEdit:9687144] Shamovsky, Veronica, 2020-05-06
[InstanceEdit:9687804] Shamovsky, Veronica, 2020-05-12
[InstanceEdit:9690135] Shamovsky, Veronica, 2020-05-26
[InstanceEdit:9927692] Shamovsky, Veronica, 2024-11-08
nameCleavage of factor XII variant by plasmin
Cleavage of F12 variant by plasmin
output[DefinedSet:9653235] F12 variant (20-328) [extracellular region] [Homo sapiens]
[DefinedSet:9653229] F12 variant (329-615) [extracellular region] [Homo sapiens]
reviewed[InstanceEdit:9673821] D'Eustachio, Peter, 2020-01-09
[InstanceEdit:9681505] Zhang, Bin, 2020-04-02
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9655056] R-HSA-9655045.1
summation[Summation:9655043] Factor XII (FXII, F12 or Hageman factor) is a serine proteas...
(hasEvent)[Pathway:9657688] Defective factor XII causes hereditary angioedema [Homo sapiens]
(precedingEvent)[Reaction:9655046] Cleavage of FXII variant by KLKB1 [Homo sapiens]
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