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Details on Person UniProt:Q80W85 Npm2
Class:Id
ReferenceGeneProduct:96540
_chainChangeLog
chain:1-207 added on Fri February 6 2015
_displayName
UniProt:Q80W85 Npm2
_timestamp
2023-11-03 16:06:03
chain
chain:1-207
checksum
8B8A8931F85032EE
comment
FUNCTION Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.SUBUNIT Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously (By similarity).SUBCELLULAR LOCATION Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.TISSUE SPECIFICITY Ovary specific.DOMAIN The acidic tract A2 mediates histone binding.SIMILARITY Belongs to the nucleoplasmin family.
description
recommendedName: Nucleoplasmin-2
geneName
Npm2
identifier
Q80W85
isSequenceChanged
FALSE
keyword
Chaperone Chromatin regulator Developmental protein Fertilization Nucleus Reference proteome
