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Details on Person factor XIIa binds HRG

Class:Id	Reaction:9653879
_displayName	factor XIIa binds HRG
_doRelease	TRUE
_timestamp	2026-01-27 16:19:43
authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9653837] Shamovsky, Veronica, 2019-07-15
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
goBiologicalProcess	[GO_BiologicalProcess:1221431] negative regulation of blood coagulation, intrinsic pathway
input	[Complex:158306] factor XIIa [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158699] HRG [extracellular region] [Homo sapiens]
internalReviewed	[InstanceEdit:9945130] D'Eustachio, Peter, 2025-04-10
literatureReference	[LiteratureReference:9653878] Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation [LiteratureReference:9855233] Identification of the histidine-rich glycoprotein domains responsible for contact pathway inhibition
modified	[InstanceEdit:9674491] Shamovsky, Veronica, 2020-01-13 [InstanceEdit:9855244] Shamovsky, Veronica, 2023-11-30 [InstanceEdit:9935200] Shamovsky, Veronica, 2025-01-13 [InstanceEdit:9938624] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938676] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938812] Shamovsky, Veronica, 2025-02-19 [InstanceEdit:9938860] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9946118] Shamovsky, Veronica, 2025-04-21 [InstanceEdit:9979562] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980357] Shamovsky, Veronica, 2026-01-27
name	factor XIIa binds HRG
output	[Complex:9653860] HRG:factor XIIa [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:158313] factor XII -> factor XIIa [Homo sapiens] [Reaction:158311] OBSOLETE_kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin_REPLACEMENT_9938539 [Homo sapiens] [Reaction:9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) [Homo sapiens] [Reaction:9857945] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst) [Homo sapiens] [Reaction:481007] Exocytosis of platelet alpha granule contents [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[Requirement:158223] Requirement by 'Zn2+ [extracellular region]'
regulationReference	[RegulationReference:9653845] Requirement by 'Zn2+ [extracellular region]' Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation
releaseDate	2026-03-25
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9653884] R-HSA-9653879.1
summation	[Summation:9653859] Histidine-rich glycoprotein (HRG) is produced in the liver a...
(hasEvent)	[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens] [Pathway:9855719] Regulation of FXIIa and plasma kallikrein activity [Homo sapiens]
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No pathways have been reviewed or authored by factor XIIa binds HRG (9653879)