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Details on Person S-Farn-Me KRAS4B binds calmodulin

Class:Id	Reaction:9653585
_displayName	S-Farn-Me KRAS4B binds calmodulin
_doRelease	TRUE
_timestamp	2020-05-27 01:41:05
authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9653584] Rothfels, Karen, 2019-07-11
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
input	[EntityWithAccessionedSequence:9647815] S-Farn-Me KRAS4B [plasma membrane] [Homo sapiens] [Complex:74294] CALM1:4xCa2+ [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9653563] Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling [LiteratureReference:9653566] Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization [LiteratureReference:9653567] Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin [LiteratureReference:9653555] Ca2+/calmodulin binds and dissociates K-RasB from membrane [LiteratureReference:9653574] The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas [LiteratureReference:9653388] K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling [LiteratureReference:9653393] K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function [LiteratureReference:9653444] Posttranslational Modifications of RAS Proteins
modified	[InstanceEdit:9664644] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665667] Rothfels, Karen, 2019-10-31 [InstanceEdit:9676028] Rothfels, Karen, 2020-02-06 [InstanceEdit:9676768] Rothfels, Karen, 2020-02-20 [InstanceEdit:9686661] Rothfels, Karen, 2020-05-04 [InstanceEdit:9690154] Rothfels, Karen, 2020-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	S-Farn-Me KRAS4B binds calmodulin
output	[Complex:9653583] S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9649732] Mature S-Farn-Me KRAS4B translocates to plasma membrane [Homo sapiens] [Reaction:9647977] ICMT methylates S-Farn RAS proteins [Homo sapiens]
regulatedBy	[NegativeRegulation:9653587] Negative regulation by 'pS181-S-Farn-Me KRAS4B [plasma membrane]'
releaseDate	2020-06-10
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9653588] R-HSA-9653585.2
summation	[Summation:9653586] KRAS4B, unique among RAS isoforms, has been shown to bind to...
(hasEvent)	[Pathway:9648002] RAS processing [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9654521] Calmodulin dissociates KRAS4B from the plasma membrane [Homo sapiens]
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No pathways have been reviewed or authored by S-Farn-Me KRAS4B binds calmodulin (9653585)