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Details on Person KRAS4B is phosphorylated on serine 181
Class:Id Reaction:9653503 _displayName KRAS4B is phosphorylated on serine 181 _doRelease TRUE _timestamp 2020-05-27 01:29:00 authored [InstanceEdit:9664643] Rothfels, Karen, 2019-10-25 catalystActivity [CatalystActivity:9653502] protein serine/threonine kinase activity of PKCZ,PRKG2 [plasma membrane] compartment [Compartment:70101] cytosol [Compartment:876] plasma membrane created [InstanceEdit:9653500] Rothfels, Karen, 2019-07-11 edited [InstanceEdit:9690121] Rothfels, Karen, 2020-05-26 input [EntityWithAccessionedSequence:9647815] S-Farn-Me KRAS4B [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] isChimeric FALSE literatureReference [LiteratureReference:9653428] PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis [LiteratureReference:9653393] K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function [LiteratureReference:9653278] AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2 [LiteratureReference:9653444] Posttranslational Modifications of RAS Proteins [LiteratureReference:9653421] Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status [LiteratureReference:9653411] Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region [LiteratureReference:9653342] Establishment of a human pancreatic tumor xenograft model: potential application for preclinical evaluation of novel therapeutic agents [LiteratureReference:9653404] Marine natural products: bryostatins in preclinical and clinical studies [LiteratureReference:9653388] K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling [LiteratureReference:9653563] Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling modified [InstanceEdit:9653600] Rothfels, Karen, 2019-07-11 [InstanceEdit:9664644] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665667] Rothfels, Karen, 2019-10-31 [InstanceEdit:9676028] Rothfels, Karen, 2020-02-06 [InstanceEdit:9676768] Rothfels, Karen, 2020-02-20 [InstanceEdit:9686661] Rothfels, Karen, 2020-05-04 [InstanceEdit:9690154] Rothfels, Karen, 2020-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name KRAS4B is phosphorylated on serine 181 output [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:9653482] pS181-S-Farn-Me KRAS4B [plasma membrane] [Homo sapiens] precedingEvent
releaseDate 2020-03-17 reviewed [InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9653504] R-HSA-9653503.2 summation [Summation:9653501] KRAS4B is phosphorylated on serine 181 by PKC theta or cGMP ... (hasEvent) [Pathway:9648002] RAS processing [Homo sapiens] (precedingEvent) [BlackBoxEvent:9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane [Homo sapiens]
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