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Details on Person KRAS4B is phosphorylated on serine 181 by PKC theta or cGMP ...
| Class:Id | Summation:9653501 |
|---|---|
| _displayName | KRAS4B is phosphorylated on serine 181 by PKC theta or cGMP ... |
| _timestamp | 2020-05-04 20:38:10 |
| created | [InstanceEdit:9653500] Rothfels, Karen, 2019-07-11 |
| modified | [InstanceEdit:9653601] Rothfels, Karen, 2019-07-11 [InstanceEdit:9686661] Rothfels, Karen, 2020-05-04 |
| text | KRAS4B is phosphorylated on serine 181 by PKC theta or cGMP dependent protein kinase 2 (PRKG2) (Bivona et al, 2006; Alvarez-Moya et al, 2010; Cho et al, 2016; reviewed in Ahearn et al, 2018). Serine 181 lies in a polybasic region unique to KRAS upstream of the CaaX motif. Phosphorylation at this position decreases the affinity of KRAS4B for the membrane and promotes internalization (Bivona et al, 2006; Barcelo et al, 2013; Jang et al, 2015). S181 phosphorylation has been shown to restrict cellular proliferation and oncogenesis in part by promoting BCL2L (also known as BCL-XL)-dependent apoptosis (Bivona et al, 2006; Mohammad et al, 1998; Kollar et al, 2014). Phosphorylation at S181 may also interfere with the binding of calmodulin to KRAS4B, thus disrupting calmodulin-dependent supression of signaling downstream of RAS (Wang et al, 2001; Villalonga et al, 2001). |
| (summation) | [Reaction:9653503] KRAS4B is phosphorylated on serine 181 [Homo sapiens] |
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