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Details on Person Cleavage of factor XII variant by activated thrombin

Class:Id	BlackBoxEvent:9653249
_displayName	Cleavage of factor XII variant by activated thrombin
_doRelease	TRUE
_timestamp	2020-05-26 22:01:41
authored	[InstanceEdit:9660568] Shamovsky, Veronica, 2019-09-09
catalystActivity	[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
catalystActivityReference	[CatalystActivityReference:9653820] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region] A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9653244] Shamovsky, Veronica, 2019-07-11
disease	[Disease:9653241] hereditary angioedema
edited	[InstanceEdit:9690131] Shamovsky, Veronica, 2020-05-26
entityFunctionalStatus	[EntityFunctionalStatus:9653254] gain_of_function of F12 variant [extracellular region]
input	[DefinedSet:9653247] F12 variant [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9653227] A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain
modified	[InstanceEdit:9653821] Shamovsky, Veronica, 2019-07-15 [InstanceEdit:9655724] Shamovsky, Veronica, 2019-07-26 [InstanceEdit:9676086] Shamovsky, Veronica, 2020-02-07 [InstanceEdit:9676350] Shamovsky, Veronica, 2020-02-13 [InstanceEdit:9681504] Shamovsky, Veronica, 2020-04-02 [InstanceEdit:9686299] Shamovsky, Veronica, 2020-04-29 [InstanceEdit:9687144] Shamovsky, Veronica, 2020-05-06 [InstanceEdit:9690135] Shamovsky, Veronica, 2020-05-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of factor XII variant by activated thrombin Cleavage of F12 variant by factor IIa
output	[DefinedSet:9653235] F12 variant (20-328) [extracellular region] [Homo sapiens] [DefinedSet:9653229] F12 variant (329-615) [extracellular region] [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9673821] D'Eustachio, Peter, 2020-01-09 [InstanceEdit:9681505] Zhang, Bin, 2020-04-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9653259] R-HSA-9653249.2
summation	[Summation:9655747] The plasma protein factor XII (FXII, F12 or Hageman factor) ...
(hasEvent)	[Pathway:9657688] Defective factor XII causes hereditary angioedema [Homo sapiens]
(precedingEvent)	[Reaction:9655046] Cleavage of FXII variant by KLKB1 [Homo sapiens]
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No pathways have been reviewed or authored by Cleavage of factor XII variant by activated thrombin (9653249)