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Details on Person Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs

Class:IdFailedReaction:9652816
_displayNameConstitutively active MAPK1 mutants are not dephosphorylated by DUSPs
_doReleaseTRUE
_timestamp2020-05-27 13:30:04
authored[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
catalystActivity[CatalystActivity:5675370] protein tyrosine/serine/threonine phosphatase activity of cytosolic MAPK DUSPs [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9652815] Rothfels, Karen, 2019-07-03
disease[Disease:1500689] cancer
edited[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
entityFunctionalStatus[EntityFunctionalStatus:9652812] loss_of_function of constitutively active MAPK1 mutants [cytosol]
input[CandidateSet:9652813] constitutively active MAPK1 mutants [cytosol] [Homo sapiens]
[SimpleEntity:29356] H2O [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9652901] Landscape of genomic alterations in cervical carcinomas
[LiteratureReference:9652991] Comprehensive genomic characterization of head and neck squamous cell carcinomas
[LiteratureReference:9652693] Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants
modified[InstanceEdit:9653122] Rothfels, Karen, 2019-07-09
[InstanceEdit:9664644] Rothfels, Karen, 2019-10-25
[InstanceEdit:9665667] Rothfels, Karen, 2019-10-31
[InstanceEdit:9676028] Rothfels, Karen, 2020-02-06
[InstanceEdit:9676768] Rothfels, Karen, 2020-02-20
[InstanceEdit:9689467] Rothfels, Karen, 2020-05-19
[InstanceEdit:9689469] Rothfels, Karen, 2020-05-19
[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
[InstanceEdit:9690154] Rothfels, Karen, 2020-05-27
[InstanceEdit:9690183] Rothfels, Karen, 2020-05-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameConstitutively active MAPK1 mutants are not dephosphorylated by DUSPs
normalReaction
releaseDate2020-06-10
reviewed[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9652820] R-HSA-9652816.2
summation[Summation:9652818] Constitutively active forms of MAPK1 have been identified at...
(hasEvent)[Pathway:9652817] Signaling by MAPK mutants [Homo sapiens]
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