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Details on Person SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer)

Class:Id	Reaction:9652580
_displayName	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer)
_doRelease	TRUE
_timestamp	2022-08-19 04:05:12
authored	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9652540] Jassal, Bijay, 2019-07-01
definition	Inhibition
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input	[Complex:265734] KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] [Homo sapiens] [DefinedSet:9652588] SU drugs [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:9652614] Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels [LiteratureReference:9652546] The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation [LiteratureReference:9652616] Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel [LiteratureReference:9652574] Sulfonylurea stimulation of insulin secretion [LiteratureReference:9652597] Studies on the mechanism of tolbutamide hypoglycemia in animal and human subjects [LiteratureReference:9652550] The tolbutamide site of SUR1 and a mechanism for its functional coupling to K(ATP) channel closure [LiteratureReference:9652619] Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides [LiteratureReference:9652587] Individual sulfonylureas and serious hypoglycemia in older people [LiteratureReference:9652586] Clinical experience with the oral antidiabetic compound, tolazamide [LiteratureReference:9652559] Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus [LiteratureReference:9652556] Glyburide and glipizide, second-generation oral sulfonylurea hypoglycemic agents [LiteratureReference:9652565] Clinical pharmacology of glipizide [LiteratureReference:9652575] Gliclazide modified release: from once-daily administration to 24-hour blood glucose control [LiteratureReference:9652600] GUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patients [LiteratureReference:9652602] A systematic review and meta-analysis of hypoglycemia and cardiovascular events: a comparison of glyburide with other secretagogues and with insulin [LiteratureReference:9652541] Glyburide: a second-generation sulfonylurea hypoglycemic agent. History, chemistry, metabolism, pharmacokinetics, clinical use and adverse effects
modified	[InstanceEdit:9652618] Jassal, Bijay, 2019-07-01 [InstanceEdit:9690266] Jassal, Bijay, 2020-05-28 [InstanceEdit:9773229] Matthews, Lisa, 2022-05-03 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10 [InstanceEdit:9773858] Matthews, Lisa, 2022-05-10 [InstanceEdit:9815564] Matthews, Lisa, 2022-08-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer)
output	[Complex:9652593] ABCC8:SU drugs [plasma membrane] [Homo sapiens]
releaseDate	2022-06-09
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9652608] R-HSA-9652580.3
summation	[Summation:9652561] Sulfonylurea (SU) drugs represent a group of anti-hyperglyce...
(hasEvent)	[Pathway:422356] Regulation of insulin secretion [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864007] Update Tracker - [Reaction:9652580] SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) - v88:[modifyText]
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No pathways have been reviewed or authored by SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (9652580)