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Details on Person MAP2K1 C121S [cytosol]

Class:Id	EntityWithAccessionedSequence:9652013
_displayName	MAP2K1 C121S [cytosol]
_timestamp	2019-06-27 20:09:19
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9652014] Rothfels, Karen, 2019-06-27
crossReference	[DatabaseIdentifier:9651825] COSMIC:COSV61068761 [DatabaseIdentifier:9651784] COSMIC:COSV61069878
disease	[Disease:6802336] hematologic cancer
endCoordinate	393
hasModifiedResidue	[ReplacedResidue:9651860] L-cysteine 121 replaced with L-serine
literatureReference	[LiteratureReference:9651920] Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
name	MAP2K1 C121S MEK1 Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Dual specificity mitogen-activated protein kinase kinase 1 MAP kinase kinase 1 MAPKK 1 ERK activator kinase 1 MAPK/ERK kinase 1
referenceEntity	[ReferenceGeneProduct:59503] UniProt:Q02750 MAP2K1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9652015] R-HSA-9652013.1
startCoordinate	2
(hasComponent)	[Complex:9652117] MAP2K1 C121S dimer [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by MAP2K1 C121S [cytosol] (9652013)