Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person ERBB2 V842I does not bind lapatinib

Class:IdFailedReaction:9650938
_displayNameERBB2 V842I does not bind lapatinib
_doReleaseFALSE
_timestamp2019-09-23 18:41:22
created[InstanceEdit:9650948] Orlic-Milacic, Marija, 2019-06-24
input[CandidateSet:9655251] ERBB2 V842I heterodimers [plasma membrane] [Homo sapiens]
[ChemicalDrug:1216521] Lapatinib [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
[LiteratureReference:9649445] High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2
modified[InstanceEdit:9650970] Orlic-Milacic, Marija, 2019-06-25
[InstanceEdit:9652373] Orlic-Milacic, Marija, 2019-06-28
[InstanceEdit:9654968] Orlic-Milacic, Marija, 2019-07-22
[InstanceEdit:9655266] Orlic-Milacic, Marija, 2019-07-23
[InstanceEdit:9662688] Orlic-Milacic, Marija, 2019-09-23
[InstanceEdit:9831215] Orlic-Milacic, Marija, 2023-03-20
nameERBB2 V842I does not bind lapatinib
normalReaction
reviewed[InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9650954] R-HSA-9650938.1
summation[Summation:9650967] ERBB2 V842I is resistant to lapatinib (Bose et al. 2013, Nag...
[Change default viewing format]
No pathways have been reviewed or authored by ERBB2 V842I does not bind lapatinib (9650938)