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Details on Person ERBB2 V842I does not bind lapatinib
| Class:Id | FailedReaction:9650938 |
| _displayName | ERBB2 V842I does not bind lapatinib |
| _doRelease | FALSE |
| _timestamp | 2019-09-23 18:41:22 |
| created | [InstanceEdit:9650948] Orlic-Milacic, Marija, 2019-06-24 |
| input | [CandidateSet:9655251] ERBB2 V842I heterodimers [plasma membrane] [Homo sapiens] [ChemicalDrug:1216521] Lapatinib [cytosol] |
| isChimeric | FALSE |
| literatureReference | [LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9649445] High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2 |
| modified | [InstanceEdit:9650970] Orlic-Milacic, Marija, 2019-06-25 [InstanceEdit:9652373] Orlic-Milacic, Marija, 2019-06-28 [InstanceEdit:9654968] Orlic-Milacic, Marija, 2019-07-22 [InstanceEdit:9655266] Orlic-Milacic, Marija, 2019-07-23 [InstanceEdit:9662688] Orlic-Milacic, Marija, 2019-09-23 [InstanceEdit:9831215] Orlic-Milacic, Marija, 2023-03-20 |
| name | ERBB2 V842I does not bind lapatinib |
| normalReaction |
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| reviewed | [InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16 |
| species | [Species:48887] Homo sapiens |
| stableIdentifier | [StableIdentifier:9650954] R-HSA-9650938.1 |
| summation | [Summation:9650967] ERBB2 V842I is resistant to lapatinib (Bose et al. 2013, Nag... |
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No pathways have been reviewed or authored by ERBB2 V842I does not bind lapatinib (9650938)