Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person SERPING1 is secreted

Class:IdBlackBoxEvent:9650473
_displayNameSERPING1 is secreted
_doReleaseTRUE
_timestamp2026-01-27 16:16:46
authored[InstanceEdit:9650469] Shamovsky, Veronica, 2019-06-21
compartment[Compartment:17957] endoplasmic reticulum lumen
[Compartment:984] extracellular region
created[InstanceEdit:9650469] Shamovsky, Veronica, 2019-06-21
edited[InstanceEdit:9690131] Shamovsky, Veronica, 2020-05-26
input[EntityWithAccessionedSequence:9650418] SERPING1 [endoplasmic reticulum lumen] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9650369] Biosynthesis of complement C1 inhibitor by Hep G2 cells. Reactivity of different glycosylated forms of the inhibitor with C1s
[LiteratureReference:9650524] Analysis of serpin secretion, misfolding, and surveillance in the endoplasmic reticulum
modified[InstanceEdit:9676086] Shamovsky, Veronica, 2020-02-07
[InstanceEdit:9676355] Shamovsky, Veronica, 2020-02-13
[InstanceEdit:9681504] Shamovsky, Veronica, 2020-04-02
[InstanceEdit:9686299] Shamovsky, Veronica, 2020-04-29
[InstanceEdit:9687144] Shamovsky, Veronica, 2020-05-06
[InstanceEdit:9690135] Shamovsky, Veronica, 2020-05-26
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9980352] Shamovsky, Veronica, 2026-01-27
nameSERPING1 is secreted
output[EntityWithAccessionedSequence:158296] SERPING1 [extracellular region] [Homo sapiens]
releaseDate2020-06-10
reviewed[InstanceEdit:9673821] D'Eustachio, Peter, 2020-01-09
[InstanceEdit:9681505] Zhang, Bin, 2020-04-02
[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9650611] R-HSA-9650473.3
summation[Summation:9650463] The plasma protease C1-inhibitor (C1INH, encoded by the SERP...
(hasEvent)[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens]
[Pathway:9855719] Regulation of FXIIa and plasma kallikrein activity [Homo sapiens]
(normalReaction)[FailedReaction:9650447] SERPING1 variant is not secreted [Homo sapiens]
(precedingEvent)[Reaction:158357] factor XIIa binds SERPING1 [Homo sapiens]
[Reaction:158399] kallikrein binds SERPING1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9984699] Update Tracker - [BlackBoxEvent:9650473] SERPING1 is secreted - v96:[modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by SERPING1 is secreted (9650473)