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Details on Person ERBB2 T862A [plasma membrane]

Class:IdEntityWithAccessionedSequence:9649434
_displayNameERBB2 T862A [plasma membrane]
_timestamp2019-06-14 15:48:59
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9649440] Orlic-Milacic, Marija, 2019-06-14
crossReference[DatabaseIdentifier:9649435] COSMIC:COSV54062276
[DatabaseIdentifier:9649438] COSMIC:COSM6907327
disease[Disease:1500689] cancer
[Disease:3310977] small intestine carcinoma
[Disease:2327989] bile duct carcinoma
[Disease:1493885] bladder carcinoma
[Disease:1500576] breast cancer
[Disease:1248674] large intestine cancer
[Disease:1614289] melanoma
[Disease:1655480] salivary gland cancer
[Disease:1500687] stomach cancer
endCoordinate1255
hasModifiedResidue[ReplacedResidue:9649437] L-threonine 862 replaced with L-alanine
literatureReference[LiteratureReference:9649445] High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2
[LiteratureReference:9649397] Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
modified[InstanceEdit:9649453] Orlic-Milacic, Marija, 2019-06-14
nameERBB2 T862A
ERBB2 Thr862Ala
HER2 T862A
HER2 Thr862Ala
referenceEntity[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9649443] R-HSA-9649434.1
startCoordinate23
(hasCandidate)[CandidateSet:9649439] ERBB2 KD mutants (lapatinib) [plasma membrane] [Homo sapiens]
(hasComponent)[Complex:9652386] ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens]
[Complex:9652427] EGF:EGFR:ERBB2 T862A [plasma membrane] [Homo sapiens]
[Complex:9652452] NRG1/2:ERBB3:ERBB2 T862A [plasma membrane] [Homo sapiens]
[Complex:9652465] ERBB2 T862A:ERBB4cyt1 heterodimers [plasma membrane] [Homo sapiens]
[Complex:9652498] ERBB2 T862A:ERBB4cyt2 heterodimer [plasma membrane] [Homo sapiens]
(hasMember)[CandidateSet:9646481] ERBB2 KD mutants [plasma membrane] [Homo sapiens]
[CandidateSet:9649436] ERBB2 KD mutants (neratinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9649458] ERBB2 KD mutants (afatinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9664578] ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] [Homo sapiens]
[CandidateSet:9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] [Homo sapiens]
[DefinedSet:9665271] ERBB2 KD mutants (AEE788 resistant) [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by ERBB2 T862A [plasma membrane] (9649434)