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Details on Person Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib

Class:IdLiteratureReference:9649397
_displayNameDifferential sensitivity of ERBB2 kinase domain mutations towards lapatinib
_timestamp2019-06-13 20:29:54
author[Person:9649400] Kancha, Rama Krishna
[Person:9649394] von Bubnoff, Nikolas
[Person:9649399] Bartosch, Natalie
[Person:2685292] Peschel, Christian
[Person:9649398] Engh, Richard A
[Person:9649391] Duyster, Justus
created[InstanceEdit:9649390] Orlic-Milacic, Marija, 2019-06-13
journalPLoS ONE
pagese26760
pubMedIdentifier22046346
titleDifferential sensitivity of ERBB2 kinase domain mutations towards lapatinib
volume6
year2011
(literatureReference)[Pathway:1227990] Signaling by ERBB2 in Cancer [Homo sapiens]
[FailedReaction:9650096] ERBB2 L755S does not bind TKIs [Homo sapiens]
[FailedReaction:9650278] ERBB2 V777L does not bind AEE788 [Homo sapiens]
[Pathway:9664565] Signaling by ERBB2 KD Mutants [Homo sapiens]
[Reaction:9664567] ERBB2 KD mutants heterodimerize [Homo sapiens]
[Reaction:9664588] ERBB2 KD mutants trans-autophosphorylate [Homo sapiens]
[Reaction:9664646] Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K [Homo sapiens]
[Reaction:9664664] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 [Homo sapiens]
[Reaction:9664918] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 [Homo sapiens]
[Reaction:9664933] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K [Homo sapiens]
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