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Details on Person EML4 binds to microtubules

Class:IdReaction:9648017
_displayNameEML4 binds to microtubules
_doReleaseTRUE
_timestamp2019-11-12 17:30:26
authored[InstanceEdit:9651264] Orlic-Milacic, Marija, 2019-06-25
compartment[Compartment:70101] cytosol
created[InstanceEdit:9648020] Orlic-Milacic, Marija, 2019-06-04
edited[InstanceEdit:9663595] Orlic-Milacic, Marija, 2019-10-07
input[Complex:9647745] EML4 homotrimer [cytosol] [Homo sapiens]
[Complex:190599] Microtubule [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9648018] Human EML4, a novel member of the EMAP family, is essential for microtubule formation
[LiteratureReference:9647748] Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain
[LiteratureReference:9663521] Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression
[LiteratureReference:9663553] Echinoderm microtubule-associated protein like protein 4, a member of the echinoderm microtubule-associated protein family, stabilizes microtubules
modified[InstanceEdit:9663523] Orlic-Milacic, Marija, 2019-10-02
[InstanceEdit:9663540] Orlic-Milacic, Marija, 2019-10-03
[InstanceEdit:9663556] Orlic-Milacic, Marija, 2019-10-03
[InstanceEdit:9663566] Orlic-Milacic, Marija, 2019-10-03
[InstanceEdit:9663567] Orlic-Milacic, Marija, 2019-10-03
[InstanceEdit:9663576] Orlic-Milacic, Marija, 2019-10-04
[InstanceEdit:9663595] Orlic-Milacic, Marija, 2019-10-07
[InstanceEdit:9667509] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameEML4 binds to microtubules
output[Complex:9648023] EML4 homotrimer:Microtubule [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9663538] Negative regulation by 'p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol]'
releaseDate2019-12-10
reviewed[InstanceEdit:9663562] Fry, Andrew M, 2019-09-30
[InstanceEdit:9663558] Lucken, Kellie, 2019-09-30
[InstanceEdit:9663559] O'Regan, Laura, 2019-09-30
[InstanceEdit:9663574] Bechstedt, Susanne, 2019-10-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9648026] R-HSA-9648017.2
summation[Summation:9648019] In interphase cells, EML4 associates with cytosolic microtub...
(hasEvent)[Pathway:9648025] EML4 and NUDC in mitotic spindle formation [Homo sapiens]
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