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Details on Person CASP1 cleaves GSDMD

Class:Id	BlackBoxEvent:9647680
_displayName	CASP1 cleaves GSDMD
_doRelease	TRUE
_timestamp	2021-04-22 04:31:22
authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
catalystActivity	[CatalystActivity:448682] cysteine-type endopeptidase activity of Caspase-1 tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9647682] Shamovsky, Veronica, 2019-06-03
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input	[EntityWithAccessionedSequence:6801577] GSDMD [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9647669] Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death [LiteratureReference:9647649] Inflammatory Caspases: Activation and Cleavage of Gasdermin-D In Vitro and During Pyroptosis [LiteratureReference:9647624] Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor [LiteratureReference:9710021] Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis
modified	[InstanceEdit:9686081] Shamovsky, Veronica, 2020-04-28 [InstanceEdit:9710023] Shamovsky, Veronica, 2020-12-25 [InstanceEdit:9710288] Shamovsky, Veronica, 2020-12-28 [InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17 [InstanceEdit:9716212] Shamovsky, Veronica, 2021-02-19 [InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CASP1 cleaves GSDMD
output	[EntityWithAccessionedSequence:9647641] GSDMD(1-275) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9647672] GSDMD(276-484) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:448702] Caspase-1 active tetramer formation [Homo sapiens] [Reaction:448673] Formation of caspase-1 p10/p20 dimer [Homo sapiens] [BlackBoxEvent:9710294] GSDMD expression mediated by IRF2, IRF1 [Homo sapiens] [Reaction:9710295] IRF2 or IRF1 binds the GSDMD gene promoter [Homo sapiens]
regulatedBy	[NegativeRegulation:9686115] Negative regulation by 'Caspase-3 [cytosol]' [NegativeRegulation:9716201] Negative regulation by 'S-(2-succinyl)-C191-GSDMD [cytosol]'
regulationReference	[RegulationReference:9686101] Negative regulation by 'Caspase-3 [cytosol]' Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages [RegulationReference:9716206] Negative regulation by 'S-(2-succinyl)-C191-GSDMD [cytosol]' Succination inactivates gasdermin D and blocks pyroptosis
releaseDate	2021-03-23
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9647698] R-HSA-9647680.3
summation	[Summation:9647657] Inflammatory caspase‑1 (CASP1) is activated within the canon...
(hasEvent)	[Pathway:5620971] Pyroptosis [Homo sapiens]
(precedingEvent)	[Reaction:9647631] GSDMD (1-275) binds PIPs [Homo sapiens] [Reaction:9647643] GSDMD (1-275) binds bacterial cardiolipin [Homo sapiens] [Reaction:9710353] GSDMD (1-275) binds cardiolipin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776264] Update Tracker - [BlackBoxEvent:9647680] CASP1 cleaves GSDMD - v77:[modifyText]
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No pathways have been reviewed or authored by CASP1 cleaves GSDMD (9647680)